Membrane transporter/Ion channel GABA Receptor 4-Aminobutyric acid

4-Aminobutyric acid

Catalog No. T0508   CAS 56-12-2
Synonyms: γ-Aminobutyric acid, 4-Aminobutanoic acid, GABA, Gamma-aminobutyric acid, Piperidic acid

4-Aminobutyric acid is the most common inhibitory neurotransmitter in the central nervous system.

4-Aminobutyric acid, CAS 56-12-2
Pack Size Availability Price/USD Quantity
50 mg In stock 38.00
100 mg In stock 50.00
200 mg In stock 65.00
500 mg In stock 104.00
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Purity 98.00%
Biological Description
Chemical Properties
Storage & Solubility Information
Description 4-Aminobutyric acid is the most common inhibitory neurotransmitter in the central nervous system.
Targets&IC50 GABA
Cell Research
GABRP-positive cell lines, KLM-1 and PK-45P, and GABRP-negative cell lines, PK-59 and KP-1N, are incubated with GABA or GABA receptor agonist Muscimol at serial concentration (0, 1, 10, 100 μmol/L) in appropriate medium supplemented with 1% FBS for 6 days. To inhibit the GABA-mediated pathway, cells are incubated with 250 μmol/L of GABAA receptor antagonist bicuculline methiodide or 1 mmol/L of GABAB receptor antagonist CGP-35348. After 6 days of exposure to either of these drugs, cell viability is measured by MTT assay as described above.(Only for Reference)
Cell lines: PDAC cell lines KLM-1, SUIT-2, KP-1N, PK-1, PK-45P, and PK-59
Synonyms γ-Aminobutyric acid , 4-Aminobutanoic acid , GABA , Gamma-aminobutyric acid , Piperidic acid
Purity 98.00%
Molecular Weight 103.12
Formula C4H9NO2
CAS No. 56-12-2


0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

Water: 10 mM

DMSO: Insoluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )


References and Literature
1. Takehara A, et al. Cancer Res. 2007, 67(20):9704-12. 2. Soltani N, et al. Proc Natl Acad Sci U S A. 2011, 108(28):11692-7. 3. Bhat R, et al. Proc Natl Acad Sci U S A. 2010, 107(6):2580-5.

Related compound libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Inhibitor Library Natural Compound Library for HTS Anti-cancer Compound Library Clinical Compound Library Anti-diabetic Compound Library Neuronal Signaling Compound Library Human Endogenous Metabolite Compound Library Ion Channel Inhibitor Library Immunology/Inflammation Compound Library GPCR Compound Library Anti-cancer Approved drug Library Anti-cancer Clinical Compound Library Anti-Metabolism Disease Compound Library Anti-obesity Compound Library Antitumor Natural Products Library Anti-cancer Drug library Drug Repurposing Library Neurotransmitter Receptor Compound Library Neurodegenerative disease-related Compound Library FDA Approved & Pharmacopeial Drug Library Anti-Alzheimer's Disease Compound Library Gut Microbial Metabolite Library

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