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(±)-Enitociclib

Name: (±)-Enitociclib
Brand: TargetMol
SKU: T13467
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13467Cas No. 1610358-53-6

Alias (±)-BAY-1251152

(±)-Enitociclib ((±)-BAY-1251152) is a racemic mixture of BAY-1251152, a highly selective inhibitor of PTEF/CDK9.

(±)-Enitociclib

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Purity: 99.29%

Catalog No. T13467Alias (±)-BAY-1251152Cas No. 1610358-53-6

(±)-Enitociclib ((±)-BAY-1251152) is a racemic mixture of BAY-1251152, a highly selective inhibitor of PTEF/CDK9.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$31	In Stock	In Stock
5 mg	$81	In Stock	In Stock
10 mg	$123	In Stock	In Stock
25 mg	$228	In Stock	In Stock
50 mg	$372	In Stock	In Stock
100 mg	$596	In Stock	In Stock
200 mg	$847	-	In Stock
1 mL x 10 mM (in DMSO)	$89	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.29%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

(±)-Enitociclib AI Summary

(±)-Enitociclib exhibits potent bioactivity as an inhibitor of CDK9/Cyclin T with an IC50 of 3.0 nM. It also demonstrates significant antiproliferative activity against human MOLM-13 cells with an IC50 of 29.0 nM. The compound shows variable effects on cell viability; it can inhibit or stimulate growth rates in HEK293T cells, while generally enhancing growth in U2OS cells and human fibroblasts. Additionally, in Thermal Shift Assays, (±)-Enitociclib induces changes in melting temperature in various protein domains, suggesting potential interactions that may stabilize those protein regions. This complex bioactivity profile highlights its diverse effects depending on the cellular context..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	(±)-Enitociclib ((±)-BAY-1251152) is a racemic mixture of BAY-1251152, a highly selective inhibitor of PTEF/CDK9.
Synonyms	(±)-BAY-1251152

Chemical Properties

Molecular Weight	404.43
Formula	C₁₉H₁₈F₂N₄O₂S
Cas No.	1610358-53-6
Smiles	COc1cc(F)ccc1-c1cc(Nc2cc(CS(C)(=N)=O)ccn2)ncc1F
Relative Density.	1.36 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (123.63 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (6.18 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4726 mL	12.3631 mL	24.7262 mL	123.6308 mL
5 mM	0.4945 mL	2.4726 mL	4.9452 mL	24.7262 mL
10 mM	0.2473 mL	1.2363 mL	2.4726 mL	12.3631 mL
20 mM	0.1236 mL	0.6182 mL	1.2363 mL	6.1815 mL
50 mM	0.0495 mL	0.2473 mL	0.4945 mL	2.4726 mL
100 mM	0.0247 mL	0.1236 mL	0.2473 mL	1.2363 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc