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(S,R,S)-AHPC-Me

🥰Excellent
Catalog No. T7752Cas No. 1948273-02-6
Alias VHL ligand 2, E3 ligase Ligand 1A

(S,R,S)-AHPC-Me (E3 ligase Ligand 1A) (VHL ligand 2) is an (S,R,S)-AHPC-based VHL ligand used to recruit the von Hippel-Lindau (VHL) protein. It is utilized in the synthesis of ARV-771, a VHL E3 ligase-based BET PROTAC degrader that effectively degrades BET proteins in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.

(S,R,S)-AHPC-Me
Other Forms of (S,R,S)-AHPC-Me:

(S,R,S)-AHPC-Me

🥰Excellent
Purity: 99.86%
Catalog No. T7752Alias VHL ligand 2, E3 ligase Ligand 1ACas No. 1948273-02-6
(S,R,S)-AHPC-Me (E3 ligase Ligand 1A) (VHL ligand 2) is an (S,R,S)-AHPC-based VHL ligand used to recruit the von Hippel-Lindau (VHL) protein. It is utilized in the synthesis of ARV-771, a VHL E3 ligase-based BET PROTAC degrader that effectively degrades BET proteins in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.
Pack SizePriceAvailabilityQuantity
25 mg$31In Stock
50 mg$48In Stock
100 mg$64In Stock
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Purity:99.86%
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Product Introduction

Bioactivity
Description
(S,R,S)-AHPC-Me (E3 ligase Ligand 1A) (VHL ligand 2) is an (S,R,S)-AHPC-based VHL ligand used to recruit the von Hippel-Lindau (VHL) protein. It is utilized in the synthesis of ARV-771, a VHL E3 ligase-based BET PROTAC degrader that effectively degrades BET proteins in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.
SynonymsVHL ligand 2, E3 ligase Ligand 1A
Chemical Properties
Molecular Weight444.59
FormulaC23H32N4O3S
Cas No.1948273-02-6
SmilesC([C@H](C(C)(C)C)N)(=O)N1[C@H](C(N[C@@H](C)C2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1
Relative Density.1.233 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Keywords

VHL ligand-2VHL ligand2VHLLigands for E3 LigaseLigandforE3LigaseLigand for E3 LigaseInhibitorinhibitE3 ligase-recruiting MoietyAHPC-Me(S,R,S)AHPCMe(S,R,S) AHPC Me
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