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(R)-(-)-Rolipram

🥰Excellent
Catalog No. T13448Cas No. 85416-75-7
Alias (R)-Rolipram, (-)-Rolipram

(R)-(-)-Rolipram ((-)-Rolipram) is an R-enantiomer of Rolipram which is a PDE4 inhibitor.

(R)-(-)-Rolipram
Other Forms of (R)-(-)-Rolipram:

(R)-(-)-Rolipram

🥰Excellent
Purity: 99.54%
Catalog No. T13448Alias (R)-Rolipram, (-)-RolipramCas No. 85416-75-7
(R)-(-)-Rolipram ((-)-Rolipram) is an R-enantiomer of Rolipram which is a PDE4 inhibitor.
Pack SizePriceAvailabilityQuantity
2 mg$39In Stock
5 mg$62In Stock
10 mg$98In Stock
25 mg$189In Stock
50 mg$352In Stock
1 mL x 10 mM (in DMSO)$97In Stock
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Purity:99.54%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
(R)-(-)-Rolipram ((-)-Rolipram) is an R-enantiomer of Rolipram which is a PDE4 inhibitor.
In vitro
The reduction of (R)-(-)-rolipram on cAMP hydrolysis and the increasement of adenylyl cyclase activator forskolin on cAMP synthesis in a dose-dependent manner inhibits caspase-1 cleavage and IL-1β secretion[1].
Synonyms(R)-Rolipram, (-)-Rolipram
Chemical Properties
Molecular Weight275.34
FormulaC16H21NO3
Cas No.85416-75-7
SmilesCOc1ccc(cc1OC1CCCC1)[C@@H]1CNC(=O)C1
Relative Density.1.155 g/cm3
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 95 mg/mL (345.03 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.6319 mL18.1594 mL36.3187 mL181.5937 mL
5 mM0.7264 mL3.6319 mL7.2637 mL36.3187 mL
10 mM0.3632 mL1.8159 mL3.6319 mL18.1594 mL
20 mM0.1816 mL0.9080 mL1.8159 mL9.0797 mL
50 mM0.0726 mL0.3632 mL0.7264 mL3.6319 mL
100 mM0.0363 mL0.1816 mL0.3632 mL1.8159 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

RolipramPhosphodiesterase (PDE)InhibitorinhibitDNAPK(R)()Rolipram(R) ( ) Rolipram
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