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(+)-Fluprostenol

Catalog No. T21224 CAS 54276-17-4

Synonyms: Fluprostenol, (+)-, Travoprost acid, AL-5848

(+)-Fluprostenol (AL-5848), an analogue of prostaglandin F2 alpha, is a prostaglandin F2α receptor PTGFR agonist and decreases the expression of Oviductal glycoprotein 1 (OVGP1).

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(+)-Fluprostenol, CAS 54276-17-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 77.00
5 mg	In stock	$ 189.00
10 mg	In stock	$ 313.00
25 mg	In stock	$ 578.00
50 mg	In stock	$ 833.00
100 mg	In stock	$ 1,150.00
1 mL * 10 mM (in DMSO)	In stock	$ 223.00

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Purity: 99.56%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

(+)-Fluprostenol (AL-5848), an analogue of prostaglandin F2 alpha, is a prostaglandin F2α receptor PTGFR agonist and decreases the expression of Oviductal glycoprotein 1 (OVGP1).

In vivo

(+)-Fluprostenol(s.c. to rats on day 18 of pregnancy) increased cervical creep, or softness, by the following day. Doses of (+)-Fluprostenol 100-fold larger were necessary to increase uterine contractions. (+)-Fluprostenol produced falls in serum progesterone concentrations, increases in 20 alpha-dihydroprogesterone concentrations, no changes in oestradiol or relaxin concentrations and a reduction in the ovarian human chorionic gonadotrophin binding capacity in vitro. (+)-Fluprostenol was less potent in inducing cervical softness when administered per vaginam, and a dose which produced softening in pregnant rats was ineffective in ovariectomized steroid-maintained pregnant or pro-oestrous rats[3].

Synonyms	Fluprostenol, (+)-, Travoprost acid, AL-5848
Molecular Weight	458.47
Formula	C23H29F3O6
CAS No.	54276-17-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 325 mg/mL (708.88 mM), Sonification is recommended.

References and Literature

1. Baryla M, Kaczynski P, Goryszewska E, Riley SC, Waclawik A. Prostaglandin F(2α) stimulates adhesion, migration, invasion and proliferation of the human trophoblast cell line HTR-8/SVneo. Placenta. 2019 Feb;77:19-29. doi: 10.1016/j.placenta.2019.01.020. Epub 2019 Jan 24. PubMed PMID: 30827352. 2. Gao L, Gao R, Mao W, Liu B, Zhang S, Tahala D, Fu C, Shen Y, Wu J, Deng Y, Li Q, Cao J. PTGFR activation promotes the expression of PTGS-2 and growth factors via activation of the PKC signaling pathway in bovine endometrial epithelial cells. Anim Reprod Sci. 2018 Dec;199:30-39. doi:10.1016/j.anireprosci.2018.10.003. Epub 2018 Oct 14. PubMed PMID: 30340853. 3. Zhang S, Liu B, Gao L, Mao W, Fu C, Duritahala D, Zhang N, Zhang Y, Shen Y, Cao J. Prostaglandin F(2α)-PTGFR signalling activation, growth factor expression and cell proliferation in bovine endometrial explants. Reprod Fertil Dev. 2017 Oct;29(11):2195-2205. doi: 10.1071/RD16144. PubMed PMID: 28298246. 4. Ahmad SF, Akoum A, Horne AW. Selective modulation of the prostaglandin F2α pathway markedly impacts on endometriosis progression in a xenograft mouse model. Mol Hum Reprod. 2015 Dec;21(12):905-16. doi: 10.1093/molehr/gav056. Epub 2015 Oct 15. PubMed PMID: 26472819.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Immunology/Inflammation Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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Keywords

(+)-Fluprostenol 54276-17-4 GPCR/G Protein Immunology/Inflammation Prostaglandin Receptor AL 5848 PTGER2 Fluprostenol, (+)- Travoprost acid Oviductal glycoprotein 1 Fluprostenol, (+) Fluprostenol inhibit Fluprostenol (+)Fluprostenol AL-5848 OVGP1 Inhibitor AL5848 inhibitor

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