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γ-Linolenic Acid methyl ester

Name: γ-Linolenic Acid methyl ester
Brand: TargetMol
SKU: T21504
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21504Cas No. 16326-32-2

Alias Methyl gamma-linolenate

γ-Linolenic Acid methyl ester (Methyl gamma-linolenate) is a weak leukotriene B4 (LTB4) receptor antagonist.

γ-Linolenic Acid methyl ester

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Purity: 98%

Catalog No. T21504Alias Methyl gamma-linolenateCas No. 16326-32-2

γ-Linolenic Acid methyl ester (Methyl gamma-linolenate) is a weak leukotriene B4 (LTB4) receptor antagonist.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$29	In Stock	In Stock

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Purity:98%

Appearance:solid

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COA HNMR

Product Introduction

Bioactivity

Description	γ-Linolenic Acid methyl ester (Methyl gamma-linolenate) is a weak leukotriene B4 (LTB4) receptor antagonist.
Targets&IC50	LTB4:1 μM (ki; GLA)
In vitro	γ-Linolenic acid methyl ester is an esterified version of the free acid which is less water soluble but more amenable for the formulation of GLA-containing diets and dietary supplements. GLA was identified as an ω-6 fatty acid which could be elongated to arachidonic acid for endogenous eicosanoid synthesis. GLA was found to be a weak leukotriene B4 (LTB4) receptor antagonist, which was able to inhibit [3H]-LTB4 binding to porcine neutrophil membranes with a Ki of 1 μM
In vivo	In an in-vivo model of LTB4-induced bronchoconstriction, γ-Linolenic acid methyl ester at a 1 mg/kg i.v. dose could result in 53% inhibition, indicating that essential fatty acids are LTB4 receptor antagonists, which may account in part for reported anti-inflammatory activities.
Synonyms	Methyl gamma-linolenate

Chemical Properties

Molecular Weight	292.46
Formula	C₁₉H₃₂O₂
Cas No.	16326-32-2
Smiles	CCCCC\C=C/C\C=C/C\C=C/CCCCC(=O)OC
Relative Density.	0.895g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

dimethyl formamide: 100 mg/mL (341.93 mM), Sonication is recommended.

DMSO: 100 mg/mL (341.93 mM), Sonication is recommended.

Solution Preparation Table

dimethyl formamide/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4193 mL	17.0964 mL	34.1927 mL	170.9636 mL
5 mM	0.6839 mL	3.4193 mL	6.8385 mL	34.1927 mL
10 mM	0.3419 mL	1.7096 mL	3.4193 mL	17.0964 mL
20 mM	0.1710 mL	0.8548 mL	1.7096 mL	8.5482 mL
50 mM	0.0684 mL	0.3419 mL	0.6839 mL	3.4193 mL
100 mM	0.0342 mL	0.1710 mL	0.3419 mL	1.7096 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc