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Endocrinology/Hormones Opioid Receptor [Leu5]-Enkephalin

[Leu5]-Enkephalin

Catalog No. T7173   CAS 58822-25-6
Synonyms: Leu-enkephalin, Leucine enkephalin, Leucyl-enkephalin
Purity 98.00%

[Leu5]-Enkephalin is an endogenous neuropeptide involved in nociception and an agonist of δ-opioid and -opioid receptors (Kis = 4.0 and 3.4 nM, respectively)

[Leu5]-Enkephalin, CAS 58822-25-6
Pack Size Availability Price/USD Quantity
10 mg Inquiry 57.00
25 mg Inquiry 113.00
50 mg Inquiry 171.00
100 mg Inquiry 256.00
1 mL * 10 mM (in DMSO) Inquiry 67.00
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Purity 98.00%
Biological Description
Chemical Properties
Storage & Solubility Information
Description [Leu5]-Enkephalin is an endogenous neuropeptide involved in nociception and an agonist of δ-opioid and -opioid receptors (Kis = 4.0 and 3.4 nM, respectively)
Targets&IC50 δ-opioid receptor;μ-opioid receptors,  
In vivo [Leu5]-Enkephalin is found in the brain, the brainstem, and the spinal cord as well as in the peripheral nervous system. Leu-Enkephalin (1 mg/kg) decreases the visceromotor response to colon distension in a mouse model of visceral pain induced by colorectal distension[1].
Synonyms Leu-enkephalin, Leucine enkephalin, Leucyl-enkephalin
Purity 98.00%
Appearance solid
Molecular Weight 555.62
Formula C28H37N5O7
CAS No. 58822-25-6

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 150 mg/mL (269.97 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Fabisiak A , Ma?gorzata Sobocińska, Elżbieta Kamysz, et al. Antinociceptive potency of enkephalins and enkephalinase inhibitors in the mouse model of colorectal distension - proof of concept[J]. Chemical Biology & Drug Design, 2018, 92(1). 2. Meunier J C , Moisand C . Binding of leu5-enkephalin and met5-enkephalin to a particulate fraction from rat cerebrum[J]. Febs Letters, 1977, 77(2):0-213.

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