Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(R)-CCG-1423 is a stereoisomer of CCG-1423. CCG-1423 is a Rho inhibitor involved in blocking signaling through myocardin-related transcription factor A (MRTF-A) and serum response factor (SRF).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | $ 263.00 | |
10 mg | Inquiry | $ 500.00 |
Description | (R)-CCG-1423 is a stereoisomer of CCG-1423. CCG-1423 is a Rho inhibitor involved in blocking signaling through myocardin-related transcription factor A (MRTF-A) and serum response factor (SRF). |
In vitro | CCG-14223 was an inhibitor for Rho/SRF pathway and displayed activity in several in vitro cancer cell functional assays. In PC-3 prostate cancer cells, CCG-1423(< 1 μmol/L) potently inhibited lysophosphatidic acid-induced DNA synthesis. CCG-1423 inhibited the growth of RhoC-overexpressing melanoma lines (A375M2 and SK-Mel-147) at nanomolar concentrations. CCG-1423 selectively stimulated apoptosis of the metastasis-prone, RhoC-overexpressing melanoma cell line (A375M2) when compared with the parental cell line (A375). CCG-1423 inhibited Rho-dependent invasion by PC-3 prostate cancer cells. The R-isomer of CCG-1423 inhibited MRTF-A-dependent cellular events, including SRF-mediated gene expression and cell migration. The efficacy of (R)-CCG-1423 was less potent than the S-isomer [1][2]. |
Molecular Weight | 454.8 |
Formula | C18H13ClF6N2O3 |
CAS No. | T23221 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: ≤0.25mg/mL
DMSO: 10mg/ml
You can also refer to dose conversion for different animals. More
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(R)-CCG-1423 T23221 Others CCG 1423 (R)CCG1423 (R) CCG 1423 CCG-1423 CCG1423 inhibitor inhibit