store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lyoniresinol is a lignan isolated from Tarenna attenuata with free radical scavenging activity (IC50 of 82.4 μM) and antioxidant activity of DPPH, showing anti-melanogenic activity. Lyoniresinol has a strong bitter taste, while its enantiomer (-)-Lyoniresinol is odorless.
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Description | Lyoniresinol is a lignan isolated from Tarenna attenuata with free radical scavenging activity (IC50 of 82.4 μM) and antioxidant activity of DPPH, showing anti-melanogenic activity. Lyoniresinol has a strong bitter taste, while its enantiomer (-)-Lyoniresinol is odorless. |
Targets&IC50 | DPPH:82.4 μM |
In vitro | The goal of the current study was to study the effects of Lyoniresinol on cytotoxicity and melanin content in murine B16F10 melanoma cells and to delineate the underlying mechanism of tyrosinase inhibition. Lyoniresinol was purified from methanol extract of Vitex negundo root and when tested in B16F10, cells showed robust anti-melanogenic activity. It caused the downregulation of microphthalmia-associated transcription factor (MITF) and tyrosinase steady state protein expression levels. Flow cytometry analysis of Lyoniresinol-treated cells showed that the latter activates extracellular receptor kinase (ERK) phosphorylation, which causes MITF protein degradation and suppression of tyrosinase activity. Lyoniresinol decreased tyrosinase activity and melanin biosynthesis in B16F10 cells by activating ERK signaling, which downregulated MITF, tyrosinase, but not TRP-1 and TRP-2 protein expression. Contingent to more vigorous in vitro and in vivo experiments, Lyoniresinol can perhaps be incorporated into clinical dermatologic use as a skin lightening agent.[2] |
Molecular Weight | 420.45 |
Formula | C22H28O8 |
CAS No. | 14464-90-5 |
store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Lyoniresinol 14464-90-5 (+)Lyoniresinol (+) Lyoniresinol inhibitor inhibit