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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T78721 | Smurf1-IN-1 | E1/E2/E3 Enzyme | |
Smurf1-IN-1, a selective E3 ubiquitin protein ligase 1 (SMURF1) inhibitor, exhibits oral activity with an IC50 of 92 nM and demonstrates considerable efficacy in a rat model of pulmonary hypertension [1]. | |||
T16904 | Smurf1-IN-A01 | A01 | Others |
Smurf1-IN-A01 (A01) is a ubiquitin ligase Smad ubiquitination regulatory factor-1 inhibitor (kd: 3.664 nM). It increases BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation. |