mlkl-in-1 — TargetMol Chemicals

Search Result

Search Results for " mlkl-in-1 "

Compounds

Cat No.	Product Name	Targets
T60885	MLKL-IN-1
	MLKL-IN-1 is a covalent inhibitor of MLKL with a Kd value of 50 μM.
T73279	MLKL-IN-5
	MLKL-IN-5 is a potent MLKL inhibitor that mediates necroptosis .
T79731	MLKL-IN-6	Necroptosis
	MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor that specifically targets the Mixed Lineage Kinase domain-like (MLKL) protein. It effectively prevents MLKL phosphorylation and oligomerization, which are crit...	Necroptosis
T81268	RIPK1-IN-17	RIP kinase
	RIPK1/3-IN-1 (Compound 10) is a selective inhibitor of both RIPK1 and RIPK3, effectively preventing necroptosis by blocking the phosphorylation of RIPK1, RIPK3, and MLKL [1].	RIP kinase
T79831	PROTAC MLKL Degrader-1
	PROTAC MLKL Degrader-1 (Compound 36) is a selective PROTAC degrader targeting MLKL, achieving a degradation maximum (D max) over 90%. The compound encompasses modified cereblon (CRBN) ligands and a lenalidomide-linker as...
T78784	RIPK3-IN-3
	RIPK3-IN-3 (compound 20) is a selective RIPK3 inhibitor that demonstrates potent activity with an IC50 value of 10 nM. This compound effectively blocks RIPK3-mediated phosphorylation of MLKL, preventing its oligomerizati...
T74681	NecroIr2
	NecroIr2, an iridium(III) complex, functions as a necroptosis inducer in cisplatin-resistant lung cancer cells (A549R). It preferentially accumulates in mitochondria, causing oxidative stress and a reduction in mitochond...
T74680	NecroIr1
	NecroIr1, an iridium(III) complex, acts as a necroptosis inducer in Cisplatin-resistant lung cancer cells (A549R). It selectively targets mitochondria, causing oxidative stress and reducing mitochondrial membrane potenti...