3
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5091 | FM-381 | FM381 | JAK |
FM381 is a potent covalent reversible inhibitor of JAK3. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively. | |||
T22333 | FM-479 | Others | |
FM-479, an FM-381 structural analog, exhibits no inhibitory potency against JAK3 or other kinases when used at the FM-381 effective dosing range (100-300 nM). FM-479 is used as a negative control for FM-381. | |||
T31832 | FM-476 | ||
FM-476 is a negative control for FM-381. |