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Cat No. | Product Name | Synonyms | Targets |
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T11082 | Dot1L-IN-2 | Histone Methyltransferase | |
Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectively. | |||
T62915 | Dot1L-IN-7 | ||
Dot1L-IN-7 (compound 25) is a selective and potent inhibitor of telomere silencing 1-like protein (DOT1L) (IC50: 1.0 μM).Dot1L-IN-7 selectively kills MLL-AF9 and does not affect the growth of E2A-HLF cells. | |||
T11081 | Dot1L-IN-1 | Histone Methyltransferase | |
The Ki value of DOT1L-in-1 is 2pm.It is a highly effective, selective and novel Dot1L inhibitor. | |||
T73637 | Dot1L-IN-1 TFA | ||
Dot1L-IN-1 TFA is a potent and selective Dot1L inhibitor, characterized by a K i of 2 pM and an IC 50 of <0.1 nM. It effectively inhibits H3K79 dimethylation (IC 50 =3 nM) and suppresses the HoxA9 promoter activity (IC 5... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01708 | DOT1L Protein, Human, Recombinant | Human | E. coli |
Histone-lysine N-methyltransferase, H3 lysine-79 specific, also known as Histone H3-K79 methyltransferase, DOT1-like protein, Lysine N-methyltransferase 4 and DOT1L, is a nucleus protein which belongs to theDOT1 famil... |