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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T17164 | Trimetrexate | CI-898 | Others |
Trimetrexate is an effective competitive inhibitor of bacterial, protozoan, and mammalian dihydrofolate reductase. | |||
T70304 | CI-898 HCl | ||
CI-898 HCl is a lipophilic antifolate inhibitor of dihydrofolate reductase (DHFR). It has enhanced binding to DHFR in the presence of the cofactor NADPH. Cl-898 HCl inhibits cell growth and halts the cell cycle at the G1... | |||
T63985 | Trimetrexate glucuronate | ||
Trimetrexate glucuronate (NSC 352122) is a folic acid antagonist that inhibits dihydrofolate reductase, which in turn blocks the synthesis of purine nucleotides and thymidylic acid, affecting DNA and RNA synthesis and ex... |