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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T61742 | CDK8-IN-11 | ||
CDK8-IN-11 is a potent and selective inhibitor of CDK8, demonstrating an IC50 of 46 nM, and effectively targets the WNT/β-catenin signaling pathway. This compound has potential applications in colon cancer research [1]. | |||
T62293 | CDK8-IN-11 hydrochloride | ||
CDK8-IN-11 hydrochloride is a selective and potent inhibitor of CDK8 (IC50: 46 nM). CDK8-IN-11 hydrochloride inhibits the WNT/β-catenin signalling pathway. CDK8-IN-11 hydrochloride can be used to study colon cancer. | |||
T72048 | CDK8-IN-12 | GSK-3 , CDK | |
CDK8-IN-12 is a selective, potent and orally active inhibitor of CDK8 (Ki: 14 nM) and is an anti-cancer agent. CDK8-IN-12 inhibits GSK-3α, GSK-3β and PCK-θ with Ki of 13 nM, 4 nM and 109 nM respectively. CDK8-IN-12 showe... | |||
T62354 | CDK8-IN-7 | ||
CDK8-IN-7 (compound 12) is a potent and selective inhibitor of cyclin-dependent kinase 8 (CDK8) (Kd: 3.5 nM). CDK8-IN-7 has shown potential for AML-cancer research. | |||
T62112 | CDK8-IN-6 | ||
CDK8-IN-6 (compound 9) is a potent inhibitor of cyclin-dependent kinase 8 (CDK8) (Kd: 13 nM), CDK8-IN-6 showed potential research value in AML cancers. |