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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T11662L | INT-777 | S-EMCA | GPCR19 |
INT-777 (S-EMCA) is a potent TGR5 agonist with an EC50 of 0.82 μM. INT-777 (S-EMCA) inhibits NLRP5-ASC inflammasome-mediated neuroinflammation via the TGR3/cAMP/PKA signaling pathway after subarachnoid hemorrhage in rats... | |||
T11662 | INT-777 R-enantiomer | S-EMCA R enantiomer | Others |
INT-777 is the R-enantiomer of INT-777, less potent than INT-777,EC50 of 4.79 μM for TGR5. |