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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T12798 | (S)-GNE-987 | Epigenetic Reader Domain | |
(S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC). | |||
T11441 | GNE-987 | Epigenetic Reader Domain | |
GNE-987 is a highly active chimeric BET degrader. GNE-987 binds equipotently to the BD1 and BD2 bromodomains of BRD4 with low nanomolar affinities (IC50: 4.7 and 4.4 nM, respectively). GNE-987 exhibits picomolar cell BRD... |