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β-Cyclodextrin

Name: β-Cyclodextrin
Brand: TargetMol
SKU: T2951
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2951Cas No. 7585-39-9

Alias NSC 269471, Cyclomaltoheptaose, Betadex, Beta-Cyclodextrin

β-Cyclodextrin (NSC 269471) is a member of the class of compounds known as oligosaccharides.

β-Cyclodextrin

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Purity: 99.92%

Catalog No. T2951Alias NSC 269471, Cyclomaltoheptaose, Betadex, Beta-CyclodextrinCas No. 7585-39-9

β-Cyclodextrin (NSC 269471) is a member of the class of compounds known as oligosaccharides.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.92%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

β-Cyclodextrin AI Summary

β-Cyclodextrin exhibits a variety of bioactivities and pharmacokinetic properties. It is known to catalyze the hydrolysis of p-nitrophenyl phosphate (p-NPP) in the presence of zinc ions (Zn²⁺) at 37°C, with a pseudo-first-order rate constant (k_obs) of 4.16E-7 s⁻¹. In rats, the compound shows a rapid time to reach maximum plasma concentration (Tmax = 1.5 hr), a high Cmax of 9251.18 nM, and a relatively long mean residence time (MRT = 5.9 hr), with an area under the concentration-time curve (AUC) of 63300.0 ng.hr.mL⁻¹, indicating prolonged plasma exposure and good oral bioavailability at 34.0%. In terms of bioactivity, β-Cyclodextrin demonstrates in vitro and in vivo reversal activity against rocuronium-induced blockage in isolated mouse hemidiaphragm and guinea pig models, with an EC50 exceeding 360,000 nM and an ED50 of 20.0 umol/kg, respectively. The compound also exhibits high survival percentages (96.4% to 96.8%) in in vitro assays against DU 145 cells, indicating non-significant cytotoxic effects. Moreover, the compound has antioxidant properties, inhibiting copper-induced human LDL peroxidation and malondialdehyde production in a dose-dependent manner, ranging from 0.11% at 2 µM to 10.72% at 200 µM. It also induces Escherichia coli pUC19 DNA cleavage and inhibits synthetic amyloid beta-42 fibrillation. β-Cyclodextrin shows bioactivity as an inhibitor and agonist in various assays: - Potency of 1.3 nM in the Cell Viability assay - Potency of 15.8 nM as an agonist of the Thyroid Stimulating Hormone Receptor - Potency of 39810.7 nM as an inhibitor of ALDH1A1 - Potency of 56234.1 nM as an inhibitor of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) - Potency of 44668.4 nM as an antagonist of farnesoid X receptor signaling - AC50 of 2.818 µM and 1.995 µM in assays for blocking Ebola Virus entry Additionally, it shows properties related to diffusion coefficients in different solvent systems and has an aqueous solubility of 1.85 g per 100 ml at room temperature. In antibacterial assays against Staphylococcus aureus, it exhibits membrane disruption and antibacterial activity. β-Cyclodextrin also shows anti-viral activity against SARS-CoV-2, inhibiting virus-induced cytotoxicity in Caco-2 and VERO-6 cells with various inhibition rates and IC50 values greater than 20,000.0 nM. It also weakly inhibits human HDAC6 enzymatic activity with slight inhibition percentages. Overall, β-Cyclodextrin displays a broad spectrum of bioactivities including enzyme inhibition, antioxidant, antiviral, and potential therapeutic properties with favorable pharmacokinetic profiles in preclinical models..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	β-Cyclodextrin (NSC 269471) is a member of the class of compounds known as oligosaccharides.
Synonyms	NSC 269471, Cyclomaltoheptaose, Betadex, Beta-Cyclodextrin

Chemical Properties

Molecular Weight	1134.98
Formula	C₄₂H₇₀O₃₅
Cas No.	7585-39-9
Smiles	C(O)[C@@H]1[C@@]2([C@H](O)C(O)[C@](O1)(O[C@@]3([C@@H](CO)O[C@@]([C@H](O)[C@H]3O)(O[C@@]4([C@@H](CO)O[C@@]([C@H](O)[C@H]4O)(O[C@@]5([C@@H](CO)O[C@](O[C@]6([C@H](O)[C@@H](O)[C@@](O[C@]7([C@H](O)[C@@H](O)[C@@](O[C@]8([C@H](O)[C@@H](O)[C@@](O2)(O[C@@H]8CO)[H])[H])(O[C@@H]7CO)[H])[H])(O[C@@H]6CO)[H])[H])([C@H](O)[C@H]5O)[H])[H])[H])[H])[H])[H])[H])[H]
Relative Density.	1.44 g/cm3. Temperature:20 °C.

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 9.71 mg/mL (8.56 mM), Sonication is recommended.

DMSO: 55 mg/mL (48.46 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8811 mL	4.4054 mL	8.8107 mL	44.0536 mL
5 mM	0.1762 mL	0.8811 mL	1.7621 mL	8.8107 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.0881 mL	0.4405 mL	0.8811 mL	4.4054 mL
20 mM	0.0441 mL	0.2203 mL	0.4405 mL	2.2027 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc