keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Protease-Activated Receptor-1 (PAR-1) Agonist TFA is a selective peptide that acts as an agonist for the proteinase-activated receptor-1 (PAR-1). Corresponding to the tethered ligand of PAR-1, this compound mimics the actions of thrombin through the PAR-1 receptor[1][2].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
50 mg | Inquiry | Inquiry | |
100 mg | Inquiry | Inquiry |
Description | Protease-Activated Receptor-1 (PAR-1) Agonist TFA is a selective peptide that acts as an agonist for the proteinase-activated receptor-1 (PAR-1). Corresponding to the tethered ligand of PAR-1, this compound mimics the actions of thrombin through the PAR-1 receptor[1][2]. |
In vitro | A Protease-Activated Receptor-1 (PAR-1) agonist triggers the activation of protein kinase C (PKC) isoforms alpha and epsilon in HT-29 colon carcinoma cells that endogenously express PAR1. This stimulation at the cellular level, induced by both the PAR-1 agonist and thrombin, leads to enhanced HT-29 cell migration and matrix adhesion through a PKCepsilon-dependent pathway. This conclusion is supported by the observation that the effects mediated by PAR1 are inhibited by bisindolylmaleimide I (a PKC inhibitor) and EAVSLKPT (a PKCepsilon translocation inhibitory peptide), but not by PKC inhibitor G? 6976[2]. |
Molecular Weight | N/A |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 6.67 mg/mL (7.61 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Protease-Activated Receptor-1, PAR-1 Agonist TFA ProteaseActivated Receptor1, PAR1 Agonist TFA Protease Activated Receptor 1, PAR 1 Agonist TFA inhibitor inhibit