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lavendustin A

Catalog No. T4183 CAS 125697-92-9

Synonyms: 薰草菌素, NSC 678027, RG-14355

lavendustin A is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase.

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lavendustin A, CAS 125697-92-9

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	lavendustin A is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase.
Targets&IC50	tyrosine kinase:11 ng/mL

Synonyms	薰草菌素, NSC 678027, RG-14355
Molecular Weight	381.384
Formula	C21H19NO6
CAS No.	125697-92-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 9.5 mg/mL(25 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Nam DH, et al. Synthesis and anticancer activity of chromone-based analogs of lavendustin A. Eur J Med Chem. 2010 Sep;45(9):4288-92 2. Löber K, et al. Influence of the tyrosine kinase inhibitors STI571 (Glivec), lavendustin A and genistein on human mast cell line (HMC-1(560)) activation. J Cell Biochem. 2008 Mar 1;103(4):1076-88 3. Lee KY, et al. Synthesis and anticancer activity of lavendustin A derivatives containing arylethenylchromone substituents. Eur J Med Chem. 2006 Aug;41(8):1991-6

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

lavendustin A 125697-92-9 JAK/STAT信号通路蛋白酪氨酸激酶蛋白酶体血管生成 Tyrosinase EGFR RG14355 ErbB-1 HER1 inhibit Inhibitor RG-14355 RG 14355 Epidermal growth factor receptor NSC 678027 inhibitor

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