Powder: -20°C for 3 years | In solvent: -80°C for 1 year
iRucaparib-AP6, a non-trapping PARP1 degrader, blocks both the catalytic activity and scaffolding effects of PARP1. iRucaparib-AP6 is a highly efficient and specific PARP1 degrader based on Rucaparib by using the PROTAC approach.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | Inquiry | $ 456.00 | |
5 mg | Inquiry | $ 1,360.00 | |
10 mg | Inquiry | $ 2,360.00 | |
50 mg | Inquiry | Inquiry | |
100 mg | Inquiry | Inquiry |
Description | iRucaparib-AP6, a non-trapping PARP1 degrader, blocks both the catalytic activity and scaffolding effects of PARP1. iRucaparib-AP6 is a highly efficient and specific PARP1 degrader based on Rucaparib by using the PROTAC approach. |
In vitro | iRucaparib-AP6 (0-10 μM; 24 hours) decreases PARP-1 level in a dose dependent manner, exhibits a half-maximal degrading concentration (DC50) of 82?nM (Dmax?=?92%). |
Molecular Weight | 886.96 |
Formula | C46H55FN6O11 |
CAS No. | 2410557-00-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (56.37 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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iRucaparib-AP6 2410557-00-3 Others iRucaparib AP6 iRucaparibAP6 iRucaparib-AP-6 inhibitor inhibit