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ferritin heavy chain fragment [Multiple species]

Catalog No. TP2248 CAS TP2248

Ferritin is a protein of 450 kDa consisting of 24 subunits that is present in every cell type. Invertebrates, these subunits are both the light (L) and the heavy (H) type with an apparent molecular weight of 19 kDA or 21 kDA respectively. The ferritin found in cancer cells was found to consist mainly of H chains. The heavy chain of Ferritin also possesses ferroxidase activity, this involves the conversion of iron from the ferrous (Fe2+) to ferric (Fe 3+) forms [1][2][3][4].

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ferritin heavy chain fragment [Multiple species] Chemical Structure

ferritin heavy chain fragment [Multiple species], CAS TP2248

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

If the ferritin level is low, there is a risk for lack of iron, which could lead to anemia. If ferritin is high, there is iron in excess or else there is an acute inflammatory reaction in which ferritin is mobilized without iron excess. For example, ferritins may be high in infection without signaling body iron overload. Ferritin is also used as a marker for iron overload disorders, such as hemochromatosis or hemosiderosis. Recent research has shown that H-Ferritin from melanoma cells may suppress immune responses [5][6][7].

Molecular Weight	1077.23
Formula	C49H80N12O15
CAS No.	TP2248

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: ≥107.7mg/mL

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Keywords

ferritin heavy chain fragment [Multiple species] TP2248 Others inhibitor inhibit

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