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Dabigatran Acyl-β-D-Glucuronide

Catalog No. T35939 CAS 1015167-40-4

Dabigatran acyl-β-D-glucuronide is a major active metabolite of the thrombin inhibitor dabigatran . The prodrug of dabigatran, dabigatran etexilate , is hydrolyzed by plasma esterases to form dabigatran, which is metabolized primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT2B15 to form dabigatran acyl-β-D-glucuronide. Dabigatran acyl-β-D-glucuronide increases activated partial thromboplastin time (aPTT) in isolated human platelet-poor plasma equipotently to dabigatran.

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Dabigatran Acyl-β-D-Glucuronide Chemical Structure

Dabigatran Acyl-β-D-Glucuronide, CAS 1015167-40-4

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	647.645
Formula	C31H33N7O9
CAS No.	1015167-40-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Dabigatran Acyl-β-D-Glucuronide 1015167-40-4 Dabigatran Acyl-beta-D-Glucuronide Dabigatran Acyl-b-D-Glucuronide Dabigatran Acyl β D Glucuronide Dabigatran AcylβDGlucuronide inhibitor inhibit

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