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BT1718

Catalog No. T80217 CAS 2227366-66-5

BT1718 is a bicyclic peptide conjugate that targets MT1-MMP, a protease overexpressed in various advanced solid tumors such as triple-negative breast cancer (TNBC) and non-small cell lung cancer [1] [2]. By exploiting MT1-MMP, BT1718 delivers its cytotoxic payload, Mertansine, with a strong affinity characterized by a dissociation constant (K D) of 3 nM.

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BT1718, CAS 2227366-66-5

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Description	BT1718 is a bicyclic peptide conjugate that targets MT1-MMP, a protease overexpressed in various advanced solid tumors such as triple-negative breast cancer (TNBC) and non-small cell lung cancer [1] [2]. By exploiting MT1-MMP, BT1718 delivers its cytotoxic payload, Mertansine, with a strong affinity characterized by a dissociation constant (K D) of 3 nM.
In vitro	BT1718 (IC50 = 1 nM, 72 h) demonstrated cytotoxicity against HT-1080 cells in an ATP endpoint assay [2].
In vivo	BT1718 (10mg/kg, intravenous injection, thrice weekly) demonstrated rapid tumor clearance in a mouse xenograft model derived from EBC-1 cells positive for MT1 [2]. Furthermore, with once or twice weekly intravenous administration of BT1718 at the same dosage, complete tumor eradication was observed in a mouse xenograft model implanted with MT1 positive HT-1080 cells [2].

Molecular Weight	N/A
Formula	C159H218ClN31O47S5
CAS No.	2227366-66-5

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Keywords

BT1718 2227366-66-5 Proteases/Proteasome MMP inhibitor inhibit

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