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ZK824859 hydrochloride (2271122-53-1 free base)

Catalog No. T13409L CAS T13409L

Synonyms: ZK824859 hydrochloride

ZK824859 hydrochloride is an oral available and selective inhibitor of urokinase plasminogen activator (uPA)(IC50s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively).

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ZK824859 hydrochloride (2271122-53-1 free base) Chemical Structure

ZK824859 hydrochloride (2271122-53-1 free base), CAS T13409L

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5 mg	Inquiry	$ 398.00
10 mg	Inquiry	$ 663.00
50 mg	Inquiry	$ 1,850.00
100 mg	Inquiry	$ 2,905.00
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1 mL * 10 mM (in DMSO)	Inquiry	$ 439.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	ZK824859 hydrochloride is an oral available and selective inhibitor of urokinase plasminogen activator (uPA)(IC50s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively).
Targets&IC50	Plasmin (human):1330 nM , TPA (human):1580 nM , uPA (human):79 nM
In vitro	ZK824859 is 5 fold less potent and has lost selectivity in mouse: uPA with IC50 of 410?nM; tPA with IC50 of 910?nM; plasmin with IC50 of 1600?nM compared to human IC50 of 79?nM, 1580?nM and 1330?nM respectively.

Synonyms	ZK824859 hydrochloride
Molecular Weight	464.89
Formula	C23H23ClF2N2O4
CAS No.	T13409L

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (268.88 mM)

References and Literature

1. Islam I, et al. Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3372-3375.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

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