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YS-49 monohydrate (132836-42-1 free base)

Catalog No. T13376L CAS T13376L

Synonyms: YS-49 monohydrate

YS-49 (monohydrate) is an activator of PI3K/Akt (a downstream target of RhoA).

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YS-49 monohydrate (132836-42-1 free base) Chemical Structure

YS-49 monohydrate (132836-42-1 free base), CAS T13376L

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	YS-49 (monohydrate) is an activator of PI3K/Akt (a downstream target of RhoA).
In vitro	In RAVSMC and RAW 264.7 cells, YS-49 (1-100?μM; 18 hours; ) concentration-dependently inhibits the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to lipopolysaccharide (LPS) plus INF-γ, with IC50 values of 22 μM and 30?μM, respectively[2].At the transcriptional level, YS-49 (10-100?μM; 18 hours; RAVSMC and RAW 264.7 cells) suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells [2].
In vivo	In male Sprague Dawley rats,YS-49 (5?mg/kg; intraperitoneal injection; 8 hours; ) treatment significantly reduces serum NOx levels in LPS-treated rats, the NOx levels reduce from 86 μM to 34 μM[2].

Synonyms	YS-49 monohydrate
Molecular Weight	404.3
Formula	C20H22BrNO3
CAS No.	T13376L

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Sun JJ, et al. YS 49, 1-(alpha-naphtylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, regulates angiotensin II-stimulated ROS production, JNK phosphorylation and vascular smooth muscle cell proliferation via the induction of heme oxygenase-1. Life Sci. 2008 Mar 12;82(11-12):600-7. 2. Kang YJ, et al. Prevention of the expression of inducible nitric oxide synthase by a novel positive inotropic agent, YS 49, in rat vascular smooth muscle and RAW 264.7 macrophages. Br J Pharmacol. 1999 Sep;128(2):357-64. 3. Hsu YH, et al. RhoA-mediated inhibition of vascular endothelial cell mobility: positive feedback through reduced cytosolic p21 and p27. J Cell Physiol. 2014 Oct;229(10):1455-65.

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Keywords

YS-49 monohydrate (132836-42-1 free base) T13376L Others YS 49 132836-42-1 YS-49 Monohydrate YS 49 monohydrate (132836 42 1 free base) YS49 Monohydrate YS49 YS-49 YS49 monohydrate (132836421 free base) YS-49 monohydrate YS 49 Monohydrate 132836-42-1 free base inhibitor inhibit

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