Powder: -20°C for 3 years | In solvent: -80°C for 1 year
YM17E is an inhibitor of ACAT with IC50 of 44 nM in rabbit liver microsomes in vitro.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 55.00 | |
5 mg | In stock | $ 112.00 | |
10 mg | In stock | $ 157.00 | |
25 mg | In stock | $ 261.00 | |
50 mg | In stock | $ 386.00 | |
100 mg | In stock | $ 575.00 | |
500 mg | In stock | $ 1,260.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 159.00 |
Description | YM17E is an inhibitor of ACAT with IC50 of 44 nM in rabbit liver microsomes in vitro. |
Targets&IC50 | ACAT (rabbit liver microsomes):44 nM |
In vitro | YM17E is potent in inhibiting ACAT activity in the intestine with IC50 of 34 nM[1]. |
In vivo | YM17E inhibits the production of [14C]cholesteryloleate from [14C]oleoyl CoA in a dose-dependent manner in both liver and intestinal microsomes used as enzyme sources[1]. YM17E (3, 5, 10 mg/kg, i.v.) significantly inhibits hepatic ACAT activities in a dose-dependent manner. YM17E (oral; i.v.) produces a significant increase in 125I-LDL clearance in atherogenic diet-fed rats. YM17E (3, 10, 30 mg/kg; p.o.) decreases total cholesterol, cholesteryl ester, and non-HDL cholesterol in a dose-dependent manner. YM17E (oral) decreases total cholesterol and cholesteryl ester levels in the liver significantly in a dose-dependent manner[2]. |
Molecular Weight | 652.91 |
Formula | C40H56N6O2 |
CAS No. | 124900-72-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 12 mg/mL (18.38 mM)
You can also refer to dose conversion for different animals. More
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YM17E 124900-72-7 Metabolism Neuroscience AChR Acyltransferase Diglyceride acyltransferase Inhibitor acyl-CoA:cholesterol acyltransferase inhibit Diacylglycerol acyltransferase mono- acylglycerol acyltransferase YM-17E inhibitor