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XP-59

Name: XP-59
Brand: TargetMol
SKU: T8419
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8419 Copy Product Info

Purity: 99.10%

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XP-59 is a potent the SARS-CoV Mpro inhibitor(Ki : 0.1 μM).

Cas No. 890402-73-0

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Pack Size	Price	USA Stock	Global Stock
5 mg	$44	In Stock	In Stock
10 mg	$71	In Stock	In Stock
25 mg	$127	In Stock	In Stock
50 mg	$193	In Stock	In Stock
100 mg	$269	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.10%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

XP-59 AI Summary

XP-59 has demonstrated a binding affinity to the N-terminal his-tagged Main protease of SARS CoV. The assay involved a fluorescence-based analysis using a Dabcyl-KTSAVLQSGFRKME-Edan peptide substrate, with a reported binding affinity constant (Ki) of 17.4 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	XP-59 is a potent the SARS-CoV Mpro inhibitor(Ki : 0.1 μM).
Targets & IC50	Mpro (SARS CoV):0.1 μM(ki)

Chemical Properties

Molecular Weight	282.3
Formula	C₁₅H₁₄N₄O₂
Cas No.	890402-73-0
Smiles	CN(C)c1ccc(cc1)C(=O)On1nnc2ccccc12
Relative Density.	1.27 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 57.5 mg/mL (203.68 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (17.71 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5423 mL	17.7117 mL	35.4233 mL	177.1165 mL
5 mM	0.7085 mL	3.5423 mL	7.0847 mL	35.4233 mL
10 mM	0.3542 mL	1.7712 mL	3.5423 mL	17.7117 mL
20 mM	0.1771 mL	0.8856 mL	1.7712 mL	8.8558 mL
50 mM	0.0708 mL	0.3542 mL	0.7085 mL	3.5423 mL
100 mM	0.0354 mL	0.1771 mL	0.3542 mL	1.7712 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.