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Vindolinine

Catalog No. TN2300 CAS 5980-02-9

Vindolinine is a natural product from Catharanthus roseus (L.) G. Don.

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Vindolinine, CAS 5980-02-9

Pack Size	Availability	Price/USD	Quantity
10 mg	Inquiry	$ 800.00
1 mL * 10 mM (in DMSO)	Inquiry	$ 550.00

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Description	Vindolinine is a natural product from Catharanthus roseus (L.) G. Don.
In vitro	Vindogentianine, a new indole alkaloid together with six known alkaloids, vindoline, vindolidine, vindolicine, Vindolinine, perivine and serpentine were isolated from leaf extract (DA) of Catharanthus roseus (L.) G. Don. Their structures were elucidated by spectroscopic methods; NMR, MS, UV and IR. Vindogentianine is a dimer containing a vindoline moiety coupled to a gentianine moiety. After 24h incubation, vindogentianine exhibited no cytotoxic effect in C2C12 mouse myoblast and β-TC6 mouse pancreatic cells (IC50>50μg/mL). Real-time cell proliferation monitoring also indicated vindogentianine had little or no effect on C2C12 mouse myoblast cell growth at the highest dose tested (200μg/mL), without inducing cell death. Vindogentianine exhibited potential hypoglycemic activity in β-TC6 and C2C12 cells by inducing higher glucose uptake and significant in vitro PTP-1B inhibition. However, in vitro α±-amylase and α±-glucosidase inhibition assay showed low inhibition under treatment of vindogentianine.
Source	Natural Products > Apocynaceae > Catharanthus

Molecular Weight	336.435
Formula	C21H24N2O2
CAS No.	5980-02-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Vindogentianine, a hypoglycemic alkaloid from Catharanthus roseus (L.) G. Don (Apocynaceae).Fitoterapia. 2015 Apr;102:182-8.

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Vindolinine 5980-02-9 Others inhibitor inhibit

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