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Valsartan-d9

Catalog No. T13282 CAS 1089736-73-1

Synonyms: CGP-48933 D9

Valsartan D9 is a deuterium-labeled valsartan. Valsartan is an antagonist of the angiotensin II receptor and for the treatment of high blood pressure and heart failure.

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Valsartan-d9, CAS 1089736-73-1

Pack Size	Availability	Price/USD	Quantity
1 mg	35 days	$ 891.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Valsartan D9 is a deuterium-labeled valsartan. Valsartan is an antagonist of the angiotensin II receptor and for the treatment of high blood pressure and heart failure.
In vitro	In ageing aorta endothelial cells, Valsartan is a synthetic antagonist of non-peptide angiotensin II type 1 receptor that dilates blood vessels and reduces blood pressure by blocking the action of angiotensin. Valsartan significantly decreases the expression of AT1R [1].The pretreatment of valsartan can inhibit TLR2 signaling and proinflammatory cytokines. The expression of AGTR1 was up-regulated after alcohol exposure and was blocked by valsartan pretreatment[2].
In vivo	In rats after MI. Heart function, Valsartan significantly attenuates the expression of TGF-β/Smad, Hif-1α and fibrosis-related protein , infarcted size, wall thickness as well as myocardial vascularization of ischaemic hearts are also significantly improved by valsartan compared with saline and hydralazine[3]. Valsartan partially reverses the effects of high-salt diet on hypertension, cardiac injuries such as fibrosis and inflammatory cell infiltration, and inhibition of aquaporin 1 and angiogenic factors; valsartan alone does not exert such effects[4]. Valsartan is an effective antidepressant/antianxiety reagent and can promote the hippocampal neurogenesis and expression of BDNF.Long-term use of valsartan (5-40 mg/kg/d, oral) increases the time spent in OFT field centers and the latency to eating in NSF, reduces the fixed time of TST and FST, and increases the preference for sucrose SPT[5].

Synonyms	CGP-48933 D9
Molecular Weight	444.57
Formula	C24H29N5O3
CAS No.	1089736-73-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Shan H, et al. Valsartan ameliorates ageing-induced aorta degeneration via angiotensin II type 1 receptor-mediated ERK activity. J Cell Mol Med. 2014 Jun;18(6):1071-80. 2. Wang Y, et al. Valsartan blocked alcohol-induced, Toll-like receptor 2 signaling-mediated inflammation in human vascular endothelial cells. Alcohol Clin Exp Res. 2014 Oct;38(10):2529-40. 3. Sui X, et al. Novel mechanism of cardiac protection by valsartan: synergetic roles of TGF-β1 and HIF-1α in Ang II-mediated fibrosis after myocardial infarction. J Cell Mol Med. 2015 Aug;19(8):1773-82. 4. Jiang Y, et al. Cardioprotective effect of valsartan in mice with short-term high-salt diet by regulating cardiac aquaporin 1 and angiogenic factor expression. Cardiovasc Pathol. 2015 Jul-Aug;24(4):224-9. 5. Ping G, et al. Valsartan reverses depressive/anxiety-like behavior and induces hippocampal neurogenesis and expression of BDNF protein in unpredictable chronic mild stress mice. Pharmacol Biochem Behav. 2014 Sep;124:5-12.

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Keywords

Valsartan-d9 1089736-73-1 Others CGP-48933 D9 Valsartan-d-9 Valsartan d9 Valsartand9 inhibitor inhibit

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