Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Umbellulone is a natural product isolated from Umbellularia californica, and stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism.
Description | Umbellulone is a natural product isolated from Umbellularia californica, and stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism. |
In vitro | Umbellulone selectively stimulates transient receptor potential ankyrin 1-expressing HEK293 cells. |
In vivo | In Trpa1+/+ mice, Umbellulone (50–250?nM/5ul) causes an acute nocioceptive response in a dose-dependent manner . Umbellulone (30-150 μg/kg; i.v.) increases meningeal blood flow in a dose-dependent manner. |
Molecular Weight | 150.22 |
Formula | C10H14O |
CAS No. | 546-78-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Umbellulone 546-78-1 Others inhibitor inhibit