Powder: -20°C for 3 years | In solvent: -80°C for 1 year
UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 135.00 | |
5 mg | In stock | $ 289.00 | |
10 mg | In stock | $ 478.00 | |
25 mg | In stock | $ 789.00 | |
50 mg | In stock | $ 1,080.00 | |
100 mg | In stock | $ 1,480.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 397.00 |
Description | UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC. |
Targets&IC50 | EED:247 nM |
In vitro | UNC6852 (10 μM; 1-72 hours) results in a decrease in the levels of both EED and EZH2. UNC6852 facilitates PRC2 degradation via VHL recruitment and reduces H3K27me3 levels and DLBCL cell proliferation. UNC6852 displays no cellular toxicity at concentrations up to 30 μM for HeLa Cells[1]. |
Molecular Weight | 832.97 |
Formula | C43H48N10O6S |
CAS No. | 2688842-08-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 95 mg/mL (114.05 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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UNC6852 2688842-08-0 Chromatin/Epigenetic PROTAC Ligands for Target Protein for PROTAC Histone Methyltransferase PROTACs inhibit Inhibitor UNC 6852 UNC-6852 EED PRC2 inhibitor