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UNC6852

Catalog No. T13954 CAS 2688842-08-0

UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC.

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UNC6852, CAS 2688842-08-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 135.00
5 mg	In stock	$ 289.00
10 mg	In stock	$ 478.00
25 mg	In stock	$ 789.00
50 mg	In stock	$ 1,080.00
100 mg	In stock	$ 1,480.00
1 mL * 10 mM (in DMSO)	In stock	$ 397.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC.
Targets&IC50	EED:247 nM
In vitro	UNC6852 (10 μM; 1-72 hours) results in a decrease in the levels of both EED and EZH2. UNC6852 facilitates PRC2 degradation via VHL recruitment and reduces H3K27me3 levels and DLBCL cell proliferation. UNC6852 displays no cellular toxicity at concentrations up to 30 μM for HeLa Cells[1].

Molecular Weight	832.97
Formula	C43H48N10O6S
CAS No.	2688842-08-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 95 mg/mL (114.05 mM), Sonification is recommended.

References and Literature

1. Potjewyd F, et al. Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader. Cell Chem Biol. 2020 Jan 16;27(1):47-56.e15.

Related compound libraries

This product is contained In the following compound libraries：

Epigenetics Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

UNC6852 2688842-08-0 Chromatin/Epigenetic PROTAC Ligands for Target Protein for PROTAC Histone Methyltransferase PROTACs inhibit Inhibitor UNC 6852 UNC-6852 EED PRC2 inhibitor

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