Powder: -20°C for 3 years | In solvent: -80°C for 1 year
UK122 is a highly effective and specific inhibitor of urokinase-type plasminogen activator (uPA) with an IC50 value of 0.2 μM. It displays negligible to minimal inhibition towards tissue-type plasminogen activator (tPA), plasmin, thrombin, and trypsin (all IC50 <100 μM). Functioning as a 4-oxazolidinone analogue, UK122 is an anticancer agent that effectively inhibits cancer cell migration and invasion.
Description | UK122 is a highly effective and specific inhibitor of urokinase-type plasminogen activator (uPA) with an IC50 value of 0.2 μM. It displays negligible to minimal inhibition towards tissue-type plasminogen activator (tPA), plasmin, thrombin, and trypsin (all IC50 >100 μM). Functioning as a 4-oxazolidinone analogue, UK122 is an anticancer agent that effectively inhibits cancer cell migration and invasion. |
In vitro | UK122 (11.1, 33.3, 100 μM; 24 h) has been observed to dose-dependently curb cell migration and markedly decrease the invasiveness of CFPAC-1 cells[1]. Additionally, at concentrations ranging from 10 to 100 μM over 48 hours, UK122 shows no impact on the growth or morphological changes of CFPAC-1 cells[1]. |
Synonyms | UK122 |
Molecular Weight | 291.31 |
Formula | C17H13N3O2 |
CAS No. | 940290-58-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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UK122 940290-58-4 UK-122 UK 122 inhibitor inhibit