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UCB9608

Name: UCB9608
Brand: TargetMol
SKU: TQ0009
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0009Cas No. 1616413-96-7

UCB9608 is a selective and orally active PI4KIIIβ inhibitor (IC50: 11 nM), selective over PI3KC2 α, β, and γ lipid kinases.

UCB9608

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Purity: 99.59%

Catalog No. TQ0009Cas No. 1616413-96-7

UCB9608 is a selective and orally active PI4KIIIβ inhibitor (IC50: 11 nM), selective over PI3KC2 α, β, and γ lipid kinases.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$50	In Stock	In Stock
5 mg	$119	In Stock	In Stock
10 mg	$173	In Stock	In Stock
25 mg	$291	In Stock	In Stock
50 mg	$416	In Stock	In Stock
100 mg	$592	In Stock	In Stock
200 mg	$798	-	In Stock
1 mL x 10 mM (in DMSO)	$130	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.59%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

UCB9608 AI Summary

UCB9608 exhibits various bioactivities, including potent inhibition of PI4K3beta with IC50 values of 11.0 nM and 37.0 nM in different assays. The compound has low clearance rates in human and mouse liver microsomes and a low potential for inhibiting human ERG and CYP3A4 enzymes. It has moderate lipophilicity (LogD = 1.47) and demonstrates good kinetic and thermodynamic solubility. The compound's efflux ratio in human Caco2 cells is 2.6, and it has a low fraction unbound in mouse blood (Fu = 0.09). Additionally, UCB9608 shows good oral bioavailability and enhances long-term graft survival by significantly inhibiting allograft rejection in a cardiac transplantation model in mice, resulting in a high survival rate in an allograft rejection model..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	UCB9608 is a selective and orally active PI4KIIIβ inhibitor (IC50: 11 nM), selective over PI3KC2 α, β, and γ lipid kinases.
Targets&IC50	PI4KIIIβ:11 nM (cell free)

Chemical Properties

Molecular Weight	410.47
Formula	C₂₀H₂₆N₈O₂
Cas No.	1616413-96-7
Smiles	COc1ccc(NC(=O)N2CCN([C@@H](C)C2)c2nc(N)nc3n(C)ncc23)c(C)c1
Relative Density.	1.42 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 70 mg/mL (170.54 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.87 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4362 mL	12.1812 mL	24.3623 mL	121.8116 mL
5 mM	0.4872 mL	2.4362 mL	4.8725 mL	24.3623 mL
10 mM	0.2436 mL	1.2181 mL	2.4362 mL	12.1812 mL
20 mM	0.1218 mL	0.6091 mL	1.2181 mL	6.0906 mL
50 mM	0.0487 mL	0.2436 mL	0.4872 mL	2.4362 mL
100 mM	0.0244 mL	0.1218 mL	0.2436 mL	1.2181 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc