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UCB7362

Catalog No. T69567 CAS 2610631-17-7

Synonyms: GLXC-26743

UCB7362 (GLXC-26743) is an orally available and potent plasmepsin X (PMX) inhibitor with anti-malarial activity.UCB7362 inhibits parasite reproduction.

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UCB7362, CAS 2610631-17-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 579.00
5 mg	In stock	$ 1,270.00
25 mg	In stock	$ 1,980.00
50 mg	In stock	$ 2,580.00
100 mg	In stock	$ 3,400.00

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Purity: 97.38%

ee: 95.03%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	UCB7362 (GLXC-26743) is an orally available and potent plasmepsin X (PMX) inhibitor with anti-malarial activity.UCB7362 inhibits parasite reproduction.
Targets&IC50	PMIX:142 nM, PMX:7 nM
In vitro	UCB7362 exhibits significantly higher potency against PMX than PMIX, with an IC50 of 7 nM for the former compared to 142 nM for the latter[1]. Additionally, UCB7362 demonstrates improved selectivity against Cat D and Renin, with an IC50 of 3889 nM and >10,000 nM, respectively[1].
In vivo	UCB7362, when administered orally at doses ranging from 10 to 60 mg/kg twice a day for 4 days, clears parasitemia from peripheral blood[1]. Furthermore, when given intravenously (IV) at 1 mg/kg and orally (PO) at 10 mg/kg in a single administration, UCB7362 exhibits moderate clearance in dogs and cynomolgus monkeys, and moderate to high clearance in rats[1].

Synonyms	GLXC-26743
Molecular Weight	479.96
Formula	C25H26ClN5O3
CAS No.	2610631-17-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Lowe MA, et al. Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362. J Med Chem. 2022 Oct 10.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Parasitic Compound Library

Related Products

Related compounds with same targets

α-Terpinene Propargite Clorsulon Benzyl benzoate Purvalanol B pCDPK1/TgCDPK1-IN-3 UCB7362 hydrochloride Piperonyl butoxide

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

UCB7362 2610631-17-7 Microbiology/Virology Parasite UCB-7362 UCB 7362 GLXC-26743 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.