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U-7524

Catalog No. T29033 CAS 645-88-5

Synonyms: 2-Aminooxyacetic acid, U 7524, Aminooxyacetic acid, U7524, AOAA

U-7524, also known as AOAA and Aminooxyacetic acid, is an inhibitor of 4-aminobutyrate aminotransferase (GABA-T). AOAA is also a general inhibitor of pyridoxal phosphate (PLP)-dependent enzymes (this includes GABA-T). It functions as an inhibitor by attacking the Schiff base linkage between PLP and the enzyme, forming oxime type complexes.

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U-7524, CAS 645-88-5

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	2-Aminooxyacetic acid, U 7524, Aminooxyacetic acid, U7524, AOAA
Molecular Weight	91.07
Formula	C2H5NO3
CAS No.	645-88-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Carmona E, Gomes C, Trolin G. Effect of aminooxyacetic acid (AOAA) on GABA levels in some parts of the rat brain. Naunyn Schmiedebergs Arch Pharmacol. 1980 May;312(1):51-5. PubMed PMID: 7393347. 2. Duvilanski BH, Seilicovich A, Díaz MC, Muñoz Maines V, Lasaga M, Debéljuk L. Effect of GABA-T inhibitors on prolactin secretion in vitro. Eur J Pharmacol. 1985 Sep 10;115(1):65-9. PubMed PMID: 4043235. 3. Neal MJ, Starr MS. Effect of inhibitors of -aminobutyrate aminotransferase on the accumulation of 3H- -aminobutyric acid by the retina. Br J Pharmacol. 1973 Mar;47(3):543-55. PubMed PMID: 4730831; PubMed Central PMCID: PMC1776273. 4. van der Laan JW, Weick G, van Bleek G. Effects of inhibitors of GABA-transaminase on hole-board exploration and on temperature. Relation with effects on quasi-morphine abstinence behaviour induced by sodium dipropylacetate. Biochem Pharmacol. 1985 Nov 1;34(21):3789-94. PubMed PMID: 3933514.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

U-7524 645-88-5 2-Aminooxyacetic acid U 7524 Aminooxyacetic acid U7524 AOAA inhibitor inhibit

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