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Trans-Tranilast

Catalog No. T2270   CAS 70806-55-2
Synonyms: Tranilast trans-

Trans-Tranilast is an antiallergic drug developed by Kissei Pharmaceuticals. It was approved in 1982 for use in Japan and South Korea for bronchial asthma. Indications for keloid and hypertrophic scar were added in 1993. It has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.

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Trans-Tranilast Chemical Structure
Trans-Tranilast, CAS 70806-55-2
Pack Size Availability Price/USD Quantity
5 mg In stock $ 54.00
10 mg In stock $ 87.00
25 mg In stock $ 148.00
50 mg In stock $ 237.00
100 mg In stock $ 353.00
200 mg In stock $ 523.00
500 mg In stock $ 837.00
1 mL * 10 mM (in DMSO) In stock $ 58.00
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Purity: 99.67%
Purity: 98%
Purity: 97.59%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Trans-Tranilast is an antiallergic drug developed by Kissei Pharmaceuticals. It was approved in 1982 for use in Japan and South Korea for bronchial asthma. Indications for keloid and hypertrophic scar were added in 1993. It has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.
In vivo Protodioscin (5 and 10 mg/kg) significantly improves glucose intolerance and reduced the levels of serum UA, BUN, Cr, TC and TG. Protodioscin significantly reduces renal concentrations of IL-1β, IL-6 and TNF-α by inhibiting the activation of nuclear factor-κB, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase and extracellular signal-regulated kinase[1]. Protodioscin ameliorates the death rate, inhibits the increase in neurological deficit scores and infarct volume, and reduces the apoptotic nerve cells induced by MCAO in rats. Protodioscin attenuates the change of relevant apoptins, suppresses the release of pro-inflammatory cytokines in serum and reverses the protein expression of NF-κB (in nucleus and cytoplasm) and IκBα (in cytoplasm) induced by MCAO in rats[2]. Protodioscin (0.5?mg/kg, i.p.) increases the coagulation time by appr?50?% as compared to that of high-fat diet control rats. Protodioscin possesses a promising effect in lowering the blood levels of both lipoproteins, especially LDL, thus resulting in a high ratio of HDL/LDL[3].
Synonyms Tranilast trans-
Molecular Weight 327.33
Formula C18H17NO5
CAS No. 70806-55-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL(183.3 mM)

TargetMolReferences and Literature

1. Rogosnitzky, M., R. Danks, and E. Kardash, Therapeutic potential of tranilast, an anti-allergy drug, in proliferative disorders. Anticancer Res, 2012. 32(7): p. 2471-8. 2. Swiderski, K., et al., Tranilast administration reduces fibrosis and improves fatigue resistance in muscles of mdx dystrophic mice. Fibrogenesis Tissue Repair, 2014. 7(1): p. 1.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compounds Library Max ReFRAME Related Library Anti-Cardiovascular Disease Compound Library FDA-Approved & Pharmacopeia Drug Library NO PAINS Compound Library Anti-Hypertension Compound Library Endocrinology-Hormone Compound Library Immunology/Inflammation Compound Library Approved Drug Library GPCR Compound Library

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Keywords

Trans-Tranilast 70806-55-2 Endocrinology/Hormones RAAS Trans Tranilast trans-SB 252218 Inhibitor Angiotensin Receptor TransTranilast Tranilast trans- trans-Tranilast inhibit inhibitor

 

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