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Toltrazuril (sulfone)

Catalog No. T5052 CAS 69004-04-2

Synonyms: Toltrazuril sulfone, Ponazuril

Toltrazuril sulfone (Ponazuril) is an antiprotozoal agent that acts upon Coccidia parasites.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Toltrazuril (sulfone) Chemical Structure

Toltrazuril (sulfone), CAS 69004-04-2

Pack Size	Availability	Price/USD
10 mg	In stock	$ 46.00
25 mg	In stock	$ 72.00
50 mg	In stock	$ 97.00
100 mg	In stock	$ 119.00
1 mL * 10 mM (in DMSO)	In stock	$ 51.00

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Purity: 99.42%

Purity: 99.21%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Toltrazuril sulfone (Ponazuril) is an antiprotozoal agent that acts upon Coccidia parasites.
In vivo	Afloqualone slightly increased the response during the alarm period in one out of 3 rats at 5, 10, and 20 mg/kg p.o., respectively.

Synonyms	Toltrazuril sulfone, Ponazuril
Molecular Weight	457.38
Formula	C18H14F3N3O6S
CAS No.	69004-04-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 33 mg/mL (72.15 mM)

References and Literature

1. Dirikolu L, Yohn R, Garrett EF, Chakkath T, Ferguson DC. Detection, quantifications and pharmacokinetics of toltrazuril sulfone (Ponazuril) in cattle. J Vet Pharmacol Ther. 2009 Jun;32(3):280-8. 2. Lim JH, Kim MS, Hwang YH, Song IB, Park BK, Yun HI. Pharmacokinetics of toltrazuril and its metabolites, toltrazuril sulfoxide and toltrazuril sulfone, after a single oral administration to pigs. J Vet Med Sci. 2010 Aug;72(8):1085-7. 3. Dirikolu L, Karpiesiuk W, Lehner AF, Tobin T. Toltrazuril sulfone sodium salt: synthesis, analytical detection, and pharmacokinetics in the horse. J Vet Pharmacol Ther. 2012 Jun;35(3):265-74. 4. Dirikolu L, Karpiesiuk W, Lehner AF, Hughes C, Granstrom DE, Tobin T. Synthesis and detection of toltrazuril sulfone and its pharmacokinetics in horses following administration in dimethylsulfoxide. J Vet Pharmacol Ther. 2009 Aug;32(4):368-78. 5. Pharmacokinetics of ponazuril after oral administration to healthy Ilamas (Lama glama) By Prado, Maria E.; Ryman, Josiah T.; Boileau, Melanie J.; Martin-Jimenez, Tomas; Meibohm, Bernd From American Journal of Veterinary Research (2011), 72(10), 1386-1389

Citations

1. Kaduk J A, Gates-Rector S, Blanton T N. Crystal structure of ponazuril, C18H14F3N3O6S. Powder Diffraction. 2022: 1-5.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Parasitic Compound Library Anti-Infection Compound Library Target-Focused Phenotypic Screening Library NO PAINS Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Toltrazuril (sulfone) 69004-04-2 Microbiology/Virology Parasite anticoccidial Inhibitor Toltrazuril sulfone inhibit sulfone Ponazuril Toltrazuril antiprotozoal inhibitor

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