Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tolmetin sodium is a non-steroidal anti-inflammatory drug (NSAID). Tolmetin sodium is an orally active and potent inhibitor of COX with IC 50s of 0.35 μM for human COX-1 and 0.82 μM for human COX-2, respectively [1] [2].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | Tolmetin sodium is a non-steroidal anti-inflammatory drug (NSAID). Tolmetin sodium is an orally active and potent inhibitor of COX with IC 50s of 0.35 μM for human COX-1 and 0.82 μM for human COX-2, respectively [1] [2]. |
In vitro | Tolmetin sodium at a concentration of 0.25 mM does not reduce lipid peroxidation in rat brain homogenate. However, Tolmetin at concentrations ranging from 0.25 to 1 mM exhibits antioxidant properties by scavenging free radicals, yet it does not induce the generation of superoxide anions in rat brain homogenate [3]. Additionally, Tolmetin sodium demonstrates dose-dependent anticancer effects against the HT-29 colon cancer cell line within the concentration range of 0.001-100 μM [4]. In contrast, concentrations of Tolmetin sodium up to 100 μM have no impact on the growth of osteoblasts [5]. |
In vivo | Tolmetin sodium, administered at dosages of 30-100 mg/kg via gavage either as a single dose or twice daily for 3 and 14 days, exhibits its peak ulcerogenic effect in male Wistar rats (180-200 g) four hours post initial dose. This effect notably diminishes following repeated administration over 3 and 14 days. Furthermore, tolmetin is associated with gastric lesions at 100 mg/kg [2]. Pre-treatment with tolmetin sodium at 5 mg/kg, administered twice daily for 5 days, significantly mitigates quinolinic acid (QA)-induced neurotoxicity [3]. |
Molecular Weight | 279.271 |
Formula | C15H14NNaO3 |
CAS No. | 35711-34-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Tolmetin sodium 35711-34-3 inhibitor inhibit