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TfR-T12 acetate

Catalog No. T40428L

Synonyms: TfR-T12 acetate (344618-30-0 Free base)

TfR-T12 acetate is a peptide binding to the transferrin receptor (TfR) and is subsequently internalized into TfR-expressing cells.

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TfR-T12 acetate, CAS N/A

Pack Size	Availability	Price/USD
1 mg	In stock	$ 87.00
5 mg	In stock	$ 176.00
10 mg	In stock	$ 293.00
25 mg	In stock	$ 527.00
50 mg	In stock	$ 762.00
100 mg	In stock	$ 1,070.00
500 mg	In stock	$ 2,130.00

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Purity: 97%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	TfR-T12 acetate is a peptide binding to the transferrin receptor (TfR) and is subsequently internalized into TfR-expressing cells.
In vitro	TfR-T12 acetate can be chemically conjugated with a pegylated lipid derivative, 3-(N-succinimidyloxyglutaryl)aminopropyl- polyethyleneglycol(2000)- carbamyl distearoyl phosphatidylethanolamine (NHS-PEG2000-DSPE), and used as a functional material to construct the multifunctional lipid vesicles[1].
In vivo	In brain glioma-bearing mice, TfR-T12 acetate is transported across the BBB, killing brain glioma and glioma stem cells via the induction of necrosis, apoptosis and autophagy[2].

Synonyms	TfR-T12 acetate (344618-30-0 Free base)
Molecular Weight	1550.78
Formula	C73H103N19O17S

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Li-Min Mu, et al. Lipid Vesicles Containing Transferrin Receptor Binding Peptide TfR-T 12 and Octa-Arginine Conjugate stearyl-R 8 Efficiently Treat Brain Glioma Along With Glioma Stem Cells. Sci Rep. 2017 Jun 14;7(1):3487. 2. Carmen Wängler, et al. In Vitro and Initial in Vivo Evaluation of (68)Ga-labeled Transferrin Receptor (TfR) Binding Peptides as Potential Carriers for Enhanced Drug Transport Into TfR Expressing Cells. Mol Imaging Biol. 2011 Apr;13(2):332-41.

Related compound libraries

This product is contained In the following compound libraries：

Peptide Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

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