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Teicoplanin aglycone

Catalog No. T26256 CAS 89139-42-4

Synonyms: TD-A3

Teicoplanin aglycone is an antibacterial glycopeptide antibiotic used in the prophylaxis and treatment of serious infections caused by Gram-positive bacteria, including Enterococcus faecalis and methicillin-resistant Staphylococcus aureus.

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Teicoplanin aglycone, CAS 89139-42-4

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	TD-A3
Molecular Weight	1198.93
Formula	C58H45Cl2N7O18
CAS No.	89139-42-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Gonnella NC, Grinberg N, Mcloughlin M, Choudhary O, Fandrick K, Ma S. Three-dimensional structure of cyclic antibiotic teicoplanin aglycone using NMR distance and dihedral angle restraints in a DMSO solvation model. Magn Reson Chem. 2015 Oct;53(10):829-35. doi: 10.1002/mrc.4279. Epub 2015 Jul 1. PubMed PMID: 26138046. 2. Bick MJ, Banik JJ, Darst SA, Brady SF. Crystal structures of the glycopeptide sulfotransferase Teg12 in a complex with the teicoplanin aglycone. Biochemistry. 2010 May 18;49(19):4159-68. doi: 10.1021/bi100150v. PubMed PMID: 20361791; PubMed Central PMCID: PMC2888265. 3. Tollas S, Bereczki I, Sipos A, Rőth E, Batta G, Daróczi L, Kéki S, Ostorházi E, Rozgonyi F, Herczegh P. Nano-sized clusters of a teicoplanin ψ-aglycon-fullerene conjugate. Synthesis, antibacterial activity and aggregation studies. Eur J Med Chem. 2012 Aug;54:943-8. doi: 10.1016/j.ejmech.2012.06.054. Epub 2012 Jul 4. PubMed PMID: 22795664. 4. Ravichandran S, Collins JR, Singh N, W Wainer I. A molecular model of the enantioselective liquid chromatographic separation of (R,S)-ifosfamide and its N-dechloroethylated metabolites on a teicoplanin aglycon chiral stationary phase. J Chromatogr A. 2012 Dec 21;1269:218-25. doi: 10.1016/j.chroma.2012.08.019. Epub 2012 Aug 10. PubMed PMID: 22917979; PubMed Central PMCID: PMC3513553.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Teicoplanin aglycone 89139-42-4 TD-A3 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.