Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tarazepide is a potent and specific antagonist of CCK-A receptor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 8-10 weeks | $ 2,120.00 | |
50 mg | 8-10 weeks | $ 2,780.00 | |
100 mg | 8-10 weeks | $ 3,700.00 |
Description | Tarazepide is a potent and specific antagonist of CCK-A receptor. |
In vivo | duodenal electric activity decreased by Tarazepide, reduces interdigestive pancreatic secretion, especially protein; reduces cephalic and early postprandial (milk) induced secretion of bicarbonate and protein.Pancreatic protein secretion to intravenous CCK-8 was little affected by atropine, but was significantly reduced by Tarazepide±Atropine; in contrast, protein secretion to intraduodenal CCK-8 was abolished by Tarazepide or atropine[1]. Leptin is administered to the animals at doses of 0.1, 1.0 or 10.0 μg/kg i.d. Tarazepide (2.5 mg/kg, i.d.), a CCK(1) receptor antagonist, is given to the rats prior to the application of leptin. CCK plasma level is measured by radioimmunoassay (RIA) following administration of leptin to the rats. Intraduodenal administration of leptin (1.0 or 10.0 microg/kg) to the fasted rats significantly and dose-dependently increases pancreatic protein and amylase outputs. Capsaicin inactivates sensory nerves or pretreatment with taracidide completely eliminates pancreatic secretory response to leptin[2]. |
Molecular Weight | 448.52 |
Formula | C28H24N4O2 |
CAS No. | 141374-81-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Tarazepide 141374-81-4 Others inhibitor inhibit