Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tankyrase Inhibitors 49 is an effective, selective, and orally bioavailable inhibitor of tankyrase (IC50: 0.1nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | $ 189.00 | |
10 mg | Inquiry | $ 329.00 | |
50 mg | Inquiry | $ 888.00 | |
100 mg | Inquiry | $ 1,400.00 | |
1 mL * 10 mM (in DMSO) | Inquiry | $ 273.00 |
Description | Tankyrase Inhibitors 49 is an effective, selective, and orally bioavailable inhibitor of tankyrase (IC50: 0.1nM). |
In vitro | Tankyrase inhibitors 49 is an optimization of the previous hit compound inhibitor 8 with improved potency and selectivity. It has excellent effects in both tankyrase assay and cellular assay (IC50: 0.1nM and 1.9nM, respectively). In addition, it is found to be a dual binder with both the nicotinamide pocket and the induced pocket of the enzymes [1]. |
In vivo | In the in vivo studies in rodents, tankyrase inhibitors 49 is found to potently inhibit TNKS2 autoparsylation ( IC50: 7.6nM). It also causes stabilization and accumulation of axin protein in SW480 cells (EC50: 4nM). In DLD-1 cells with truncated APC, the inhibitor inhibits the STF reporter transcription ( IC50: 0.3nM) suggesting its downstream inhibitory activity on Wnt-associated transcription [1]. |
Molecular Weight | 448.54 |
Formula | C24H24N4O3S |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: ≥22.45mg/mL
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Tankyrase Inhibitors (TNKS) 49 Others inhibitor inhibit