Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Taltobulin trifluoroacetate is a synthetic analogue of the tripeptide hemiasterlin, is a potent agent of antimicrotubule that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.
Description | Taltobulin trifluoroacetate is a synthetic analogue of the tripeptide hemiasterlin, is a potent agent of antimicrotubule that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. |
In vitro | The growth of 18 tumor cell lines (leukemia, ovarian, NSCLC, breast, colon, and melanoma cell lines) inhibited by Taltobulin (HTI-286; 0.2-7.3 nM; 3 days)(with an average IC50 of 2.5±2.1 nM and a median value of 1.7 nM). |
In vivo | In athymic nu/nu female mice, Taltobulin (HTI-286; 1.6 mg/kg i.v.) inhibits the growth of human tumor xenografts (e.g., HCT-15, DLD-1, MX-1W, and KB-8-5) . Taltobulin (HTI-286; 3 mg/kg; p.o. gavage) inhibits growth by 97.3 % and 82% in athymic nu/nu female mice with Lox melanoma xenografts and KB-3-1 epidermoid xenograft model, respectively. |
Synonyms | HTI-286 trifluoroacetate, SPA-110 trifluoroacetate |
Molecular Weight | 587.681 |
Formula | C29H44F3N3O6 |
CAS No. | 228266-41-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 39 mg/mL (66.36 mM)
You can also refer to dose conversion for different animals. More
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Taltobulin trifluoroacetate 228266-41-9 Others SPA 110 Trifluoroacetate SPA110 Trifluoroacetate Taltobulin Trifluoroacetate SPA-110 Trifluoroacetate HTI-286 trifluoroacetate HTI 286 Trifluoroacetate HTI286 Trifluoroacetate HTI-286 Trifluoroacetate SPA-110 trifluoroacetate inhibitor inhibit