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Taltobulin hydrochloride (228266-40-8 free base)

Catalog No. T13073L CAS T13073L

Synonyms: SPA-110 hydrochloride, Taltobulin hydrochloride, HTI-286 hydrochloride

Taltobulin hydrochloride is a synthetic analogue of the tripeptide hemiasterlin, is a potent agent of antimicrotubule that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.

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Taltobulin hydrochloride (228266-40-8 free base) Chemical Structure

Taltobulin hydrochloride (228266-40-8 free base), CAS T13073L

Pack Size	Availability	Price/USD
5 mg	Inquiry	$ 206.00
10 mg	Inquiry	$ 320.00
50 mg	Inquiry	$ 971.00
100 mg	Inquiry	Inquiry
200 mg	Inquiry	Inquiry
1 mL * 10 mM (in DMSO)	Inquiry	$ 230.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Taltobulin hydrochloride is a synthetic analogue of the tripeptide hemiasterlin, is a potent agent of antimicrotubule that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.
In vitro	The growth of 18 tumor cell lines (leukemia, ovarian, NSCLC, breast, colon, and melanoma cell lines) inhibited by Taltobulin (HTI-286; 0.2-7.3 nM; 3 days)(with an average IC50 of 2.5±2.1 nM and a median value of 1.7 nM).
In vivo	In athymic nu/nu female mice, Taltobulin (HTI-286; 1.6 mg/kg i.v.) inhibits the growth of human tumor xenografts (e.g., HCT-15, DLD-1, MX-1W, and KB-8-5) . Taltobulin (HTI-286; 3 mg/kg; p.o. gavage) inhibits growth by 97.3 % and 82% in athymic nu/nu female mice with Lox melanoma xenografts and KB-3-1 epidermoid xenograft model, respectively.

Synonyms	SPA-110 hydrochloride, Taltobulin hydrochloride, HTI-286 hydrochloride
Molecular Weight	510.11
Formula	C27H44ClN3O4
CAS No.	T13073L

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (196.04 mM)

References and Literature

1. Loganzo F, et al. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res. 2003 Apr 15;63(8):1838-45.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

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