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TRC160334

Catalog No. T38693 CAS 1293289-69-6

Synonyms: TRC160334

TRC160334 is a hydroxylase inhibitor of hypoxia-inducible factor (HIF). It is employed in research about ischemia/reperfusion injury.

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TRC160334, CAS 1293289-69-6

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Description	TRC160334 is a hydroxylase inhibitor of hypoxia-inducible factor (HIF). It is employed in research about ischemia/reperfusion injury.
In vitro	TRC160334 treatment (100~400 μM; 4 hours; Hep3B cells) leads to dose-dependent stabilization and transcriptional activation of nuclear HIF-1, as evidenced by Western Blot Analysis. Additionally, TRC160334 at concentrations ranging from 75~300 μM for 4 hours in Hep3B cells induces dose-dependent expression of HIF-targeted genes, such as EPO and adrenomedullin, showcasing its impact on cellular responses through HIF-1 pathway modulation.
In vivo	In studies with Sprague-Dawley male rats (250–300 g), TRC160334 at doses of 0.1 and 0.3 mg/kg administered intraperitoneally (i.p.) notably lowered serum creatinine and blood urea nitrogen, indicative of renal function improvement. When the dosage was increased to 0.3 and 0.6 mg/kg (i.p.), TRC160334 demonstrated a tendency to mitigate acute tubular necrosis. Moreover, the compound effectively moderated dose-dependent increases in electrolyte excretion. Interestingly, pre-ischemic treatment with TRC160334 led to a significant elevation of HSP70 in kidneys within 6 hours, whereas post-ischemic treatment achieved a similar induction by 12 hours, compared to control groups. These findings suggest TRC160334's potential in protecting against kidney damage and promoting renal recovery.

Synonyms	TRC160334
Molecular Weight	337.35
Formula	C14H15N3O5S
CAS No.	1293289-69-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Jamadarkhana P, et al. Treatment with a novel hypoxia-inducible factor hydroxylase inhibitor (TRC160334) ameliorates ischemic acute kidney injury. Am J Nephrol. 2012;36(3):208-218.

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Keywords

TRC160334 1293289-69-6 TRC-160334 TRC 160334 inhibitor inhibit

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