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TRAM 39

Name: TRAM 39
Brand: TargetMol
SKU: T23471
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23471Cas No. 197525-99-8

Alias ZINC27105797, TRAM-39, 2-Chloro-alpha,alpha-diphenylbenzeneacetonitrile, 2-(2-chlorophenyl)-2,2-diphenylacetonitrile

TRAM 39 (2-Chloro-α,α-diphenylbenzeneacetonitrile) is a selective blocker of intermediate-conductance Ca2+-activated K+channels.

TRAM 39

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Purity: 99.97%

Catalog No. T23471Alias ZINC27105797, TRAM-39, 2-Chloro-alpha,alpha-diphenylbenzeneacetonitrile, 2-(2-chlorophenyl)-2,2-diphenylacetonitrileCas No. 197525-99-8

TRAM 39 (2-Chloro-α,α-diphenylbenzeneacetonitrile) is a selective blocker of intermediate-conductance Ca2+-activated K+channels.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	-	In Stock
2 mg	$42	-	In Stock
5 mg	$68	-	In Stock
10 mg	$109	-	In Stock
25 mg	$222	-	In Stock
50 mg	$353	-	In Stock
100 mg	$558	-	In Stock
500 mg	$1,180	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.97%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	TRAM 39 (2-Chloro-α,α-diphenylbenzeneacetonitrile) is a selective blocker of intermediate-conductance Ca2+-activated K+channels.
In vitro	In coeliac neurons, TRAM 39 depressed the amplitude of the prolonged conductance underlying the slow afterhyperpolarization, (gKCa2) by 57%[1].
Synonyms	ZINC27105797, TRAM-39, 2-Chloro-alpha,alpha-diphenylbenzeneacetonitrile, 2-(2-chlorophenyl)-2,2-diphenylacetonitrile

Chemical Properties

Molecular Weight	303.78
Formula	C₂₀H₁₄ClN
Cas No.	197525-99-8
Smiles	C(C#N)(C1=C(Cl)C=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3
Relative Density.	1.193 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (164.59 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2919 mL	16.4593 mL	32.9186 mL	164.5928 mL
5 mM	0.6584 mL	3.2919 mL	6.5837 mL	32.9186 mL
10 mM	0.3292 mL	1.6459 mL	3.2919 mL	16.4593 mL
20 mM	0.1646 mL	0.8230 mL	1.6459 mL	8.2296 mL
50 mM	0.0658 mL	0.3292 mL	0.6584 mL	3.2919 mL
100 mM	0.0329 mL	0.1646 mL	0.3292 mL	1.6459 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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