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TP0427736

Catalog No. T24897 CAS 864374-00-5

Synonyms: TP427736, TP-0427736, TP-427736

TP0427736 is a potent and selective inhibitor of ALK5 with an IC50 of 2.72 nM, 300-fold higher than the inhibitory effect on ALK3. TP0427736 reduces TGF-β-induced growth inhibition in human outer root sheath cells and elongates the anagen phase in mouse hair follicles.

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TP0427736, CAS 864374-00-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 97.00
5 mg	In stock	$ 238.00
10 mg	In stock	$ 389.00
25 mg	In stock	$ 663.00
50 mg	In stock	$ 945.00
1 mL * 10 mM (in DMSO)	In stock	$ 269.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	TP0427736 is a potent and selective inhibitor of ALK5 with an IC50 of 2.72 nM, 300-fold higher than the inhibitory effect on ALK3. TP0427736 reduces TGF-β-induced growth inhibition in human outer root sheath cells and elongates the anagen phase in mouse hair follicles.
Targets&IC50	ALK5:2.72 nM

Synonyms	TP427736, TP-0427736, TP-427736
Molecular Weight	298.39
Formula	C14H10N4S2
CAS No.	864374-00-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 65 mg/ml (217.84 mM)

References and Literature

1. Naruse T, et al. Novel ALK5 inhibitor TP0427736 reduces TGF-β　induced growth inhibition in human outer root sheath cells and elongates anagen phase in mouse hair follicles. Pharmacol Rep. 2017 Jun;69(3):485-491. 2. Amada H, et al. Discovery of 7-methoxy-6-[4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole (TASP0382088): a potent and selective transforming growth factor-β type I receptor inhibitor as a topical drug for alopecia. Chem Pharm Bull (Tokyo). 2013;61(3):286-91.

Related compound libraries

This product is contained In the following compound libraries：

TGF-beta/Smad Compound Library Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library Anti-Ovarian Cancer Compound Library Anti-Colorectal Cancer Compound Library Anti-Liver Cancer Compound Library Anti-Breast Cancer Compound Library Anti-Cancer Compound Library Anti-Pancreatic Cancer Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TP0427736 864374-00-5 Stem Cells TGF-beta/Smad TP427736 TP 0427736 TP-0427736 TP-427736 TP 427736 inhibitor inhibit

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