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TOK-8801

Catalog No. T13180 CAS 105963-46-0

TOK-8801 is a synthetic dihydroimidazole thiazole carboxamide with immunomodulatory activity that eliminates the stimulatory effects of antibody production by removing T cells.CAS 번호128-63-63-5

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TOK-8801, CAS 105963-46-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 293.00
5 mg	In stock	$ 722.00
10 mg	In stock	$ 987.00
25 mg	In stock	$ 1,520.00
50 mg	In stock	$ 1,980.00
100 mg	In stock	$ 2,500.00

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Purity: 99.25%

Biological Description

Chemical Properties

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Description	TOK-8801 is a synthetic dihydroimidazole thiazole carboxamide with immunomodulatory activity that eliminates the stimulatory effects of antibody production by removing T cells.CAS 번호128-63-63-5
In vitro	TOK-8801 enhanced the anti-sheep red blood cells (SRBC) plaque forming cells (PFC) response and mitogen-induced proliferative responses in murine splenocytes and thymocytes in vitro at concentrations of 10(-7)-10(-5) M, while LMS augmented these responses at 10(-4) M[1].
In vivo	TOK-8801 (0.5 mg/kg, p.o.) suppressed the production of anti-SRBC PFC in normal mice, but restored the inhibition of antibody production in restraint stress mice[1].

Molecular Weight	315.43
Formula	C17H21N3OS
CAS No.	105963-46-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Fujiwara M,et al. Immunomodulatory activity of the newly synthesized compound TOK-8801 (N-(2-phenylethyl)-3,6,6-trimethyl-5,6-dihydroimidazo[2,1-b]thiazole-2- carboxamide). Jpn J Pharmacol. 1989 Dec;51(4):549-54. 2. Shibata K,et al. Immunomodulatory effect of a newly synthesized compound, TOK-8801 (N-(2-phenylethyl)-3,6,6-trimethyl-5,6-dihydroimidazo [2,1-b]thiazole-2-carboxamide) on antibody production in vivo and delayed-type hypersensitivity in mice. Int J Immunopharmacol. 1990;12(5):497-502.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TOK-8801 105963-46-0 Others TOK 8801 TOK8801 inhibitor inhibit

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