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TMB 8 (hydrochloride)

Catalog No. T36554 CAS 53464-72-5

TMB 8 is a non-competitive antagonist of nicotinic acetylcholine receptors (nAChRs) with IC50 values of 390 and 350 nM, respectively, for human muscle-type and α3β4 subunit-containing ganglionic nAChRs expressed in TE671/RD or SH-SY5Y cells. It inhibits nicotine-induced dopamine release from rat brain synaptosomes (IC50 = 480 nM). TMB 8 also reduces calcium availability in smooth and skeletal muscle, blocking the contractile response in isolated rabbit aortic strip when used at a concentration of 50 μM and inhibiting calcium influx and efflux in isolated guinea pig ileum when used at a concentration of 65 μM. It has been used in the study of intracellular calcium dynamics, particularly in smooth muscle. TMB 8 also inhibits protein kinase C (PKC) activity in a dose-dependent manner.

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TMB 8 (hydrochloride) Chemical Structure

TMB 8 (hydrochloride), CAS 53464-72-5

Pack Size	Availability	Price/USD	Quantity
5 mg	35 days	$ 68.00
10 mg	35 days	$ 125.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	431.99
Formula	C22H38ClNO5
CAS No.	53464-72-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Methanol: Slightly soluble

H2O: Slightly soluble

Chloroform: Slightly soluble

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TMB 8 (hydrochloride) 53464-72-5 TMB-8 TMB 8 TMB8 inhibitor inhibit

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